Biologics

Authors: Boland L1, Danger R, Cabon Q, Rabillard M, Brouard S, Bouvy B, Gauthier O.
Journal: Vet Comp Orthop Traumatol

Objectives: To measure the activity of matrix metalloproteinases (MMP)-2 and -9 in synovial fluid from the stifle joints of dogs with cranial cruciate ligament (CrCL) rupture and to compare that to values from contralateral stifle joints and dogs with clinically normal stifle joints. Additionally, the C-reactive protein (CRP) levels were also measured. Methods: Fourteen large breed dogs with unilateral CrCL rupture and 11 large breed normal dogs were included in this prospective clinical study.

Authors: Lacitignola L1, Staffieri F, Rossi G, Francioso E, Crovace A.
Journal: Vet Comp Orthop Traumatol

Objective: The aim of this study was to track the survival and efficacy of allogeneic bone marrow mesenchymal stem cells (BM-MSC) marked with red fluorescent protein (BM-MSCRFP) in an ovine model of collagenase-induced tendinopathy. Methods: Bone marrow was harvested from one donor sheep and BM-MSC were isolated, cultivated and transfected with red fluorescent protein (BM-MSCRFP). Collagenase was injected into both Achilles tendons in the remaining nine sheep.

Authors: Trencart P, Elce YA1, Rodriguez Batista E, Michaud G.
Journal: VCOT

Introduction: Ethylene oxide is currently recommended for sterilization of antibiotic impregnated beads; however this method carries health risks to personnel and is becoming less available. Objective: To perform a pilot study of the effect of radiation for sterilization of polymethylmethacrylate (PMMA) and plaster of Paris (POP) beads impregnated with amikacin, enrofloxacin, and ceftiofur. Hypothesis: Radiation would effectively sterilize the beads without affecting the efficacy of the antibiotic.

Authors: Trencart P, Elce YA1, Rodriguez Batista E, Michaud G.
Journal: VCOT

Introduction: Ethylene oxide is currently recommended for sterilization of antibiotic impregnated beads; however this method carries health risks to personnel and is becoming less available. Objective: To perform a pilot study of the effect of radiation for sterilization of polymethylmethacrylate (PMMA) and plaster of Paris (POP) beads impregnated with amikacin, enrofloxacin, and ceftiofur. Hypothesis: Radiation would effectively sterilize the beads without affecting the efficacy of the antibiotic.

Authors: Hayes GM1, Gibson TW, Moens NM, Monteiro B, Johnson RJ.
Journal: Vet Surg

OBJECTIVE:
To investigate local and systemic pharmacokinetics of gentamicin after intra-articular implantation of a gentamicin impregnated collagen sponge (GICS) in the inflamed canine joint.
STUDY DESIGN:
Descriptive repeated measures experimental study.
ANIMALS:
Dogs (n = 9).
METHODS:

Category: Biologics
Authors: Rousseau M1, Anderson DE, Lillich JD, Apley MD, Jensen PJ, Biris AS.
Journal: AJVR

Objective-To determine the response of cortical bone to a multicomponent and nanostructural polymeric matrix as a drug delivery system for enhancing bone healing. Animals-20 healthy adult crossbred goats.

Authors: Etchepareborde S, Barthelemy N, Brunel L, Claeys S, Balligand M.
Journal: VCOT

Objectives: to evaluate in vitro the strength of different compositions of beta-tricalcium phosphate (β-TCP) wedges in comparison with titanium foam and cages. To study the response to cyclic loading of the strongest β-TCP wedge, titanium foam and titanium cage. Methods: Compression test: Twenty-five tibiae were prepared for tibial tuberosity advancement using the modified Maquet technique.

Authors: Warnock JJ1, Spina J2, Bobe G3, Duesterdieck-Zellmer KF2, Ott J2, Baltzer WI2, Bay BK4.
Journal: Vet J

Meniscal injury is a common cause of canine lameness. Tissue engineered bioscaffolds may be a treatment option for dogs suffering frommeniscal damage. The aim of this study was to compare in vitro meniscal-like matrix formation and biomechanical properties of porcine intestinal submucosa sheets (SIS), used in canine meniscal regenerative medicine, to synoviocyte-seeded SIS bioscaffold (SSB), cultured with fetal bovine serum (SSBfbs) or chondrogenic growth factors (SSBgf).

Category: Biologics - Knee