Biologics

Authors: Youkhanna D, Griffon DJ, Fredericks P, Schaeffer D, Fan TM, Jasiuk IM.
Journal: Vet Surg

OBJECTIVES:
To compare the ability of N-terminal telopeptide (NTx) assays and dual-energy x-ray absorptiometry (DEXA) to detect bone resorption in dogs with nonneoplastic bone lysis and evaluate the correlation between these diagnostic tools.
STUDY DESIGN:
Prospective, cross-sectional clinical study.
ANIMALS:
Dogs (n = 35; 39 femoral heads) that had femoral head and neck ostectomy and 6 cadaver specimens from healthy immature small dogs.
METHODS:

Category: Biologics - Hip - Imaging
Authors: Kuipers von Lande RG, Worth AJ, Guerrero TG, Owen MC, Hartman A.
Journal: Vet Surg

OBJECTIVE:
To compare radiographic healing and clinical outcome of a frontal-opening wedge osteotomy of canine tibiae when the osteotomy site is packed with either a novel bovine xenograft or standard autogenous cancellous bone graft (ACBG).
STUDY DESIGN:
Cohort study.
ANIMALS:
Dogs (n = 82) with partial or complete rupture of the cranial cruciate ligament that had tibial tuberosity advancement (TTA).
METHODS:

Authors: Nishida H, Nakayama M, Tanaka H, Kitamura M, Hatoya S, Sugiura K, Harada Y, Suzuki Y, Ide C, Inaba T.
Journal: Vet Surg

OBJECTIVE: To assess the feasibility and safety of transplantation of autologous bone marrow stromal cell (BMSC) in dogs with acute spinal cord injury (SCI). STUDY DESIGN: An open-label single-arm trial. ANIMALS: Dogs (n = 7) with severe SCI from T6 to L5, caused by vertebral fracture and luxation. METHODS: Decompressive and stabilization surgery was performed on dogs with severe SCI caused by vertebral fracture and luxation. Autologous BMSCs were obtained from each dog's femur, cultured, and then injected into the lesion in the acute stage.

Authors: von Plocki SC, Armbruster D, Klein K, Kämpf K, Zlinszky K, Hilbe M, Kronen P, Gruskin E, von Rechenberg B.
Journal: Vet Surg

OBJECTIVE:
To evaluate biocompatibility of biodegradable sleeves containing antimicrobial agents, designed for local drug delivery to prevent implant-related infection.
STUDY DESIGN:
Synthetic polyester sleeves (a copolymer of glycolide, caprolactone, trimethylene carbonate, lactide) were cast as thin films. The antimicrobial agents incorporated in the sleeves included gentamicin sulfate, triclosan, or a combination of these drugs.
ANIMALS:
Adult sheep (n = 15).
METHODS:

Authors: Bronzini I, Patruno M, Iacopetti I, Martinello T.
Journal: Vet J

Cell-based therapies, such as the use of mesenchymal stromal cells (MSCs), are becoming popular in veterinary medicine. When MSCs are not cryopreserved, they are shipped in suspension, but no previous studies have analyzed MSC viability during delivery. Here, the impact of several experimental shipping conditions on the number of equine blood-derived (ePB-MSC) and canine adipose-derived (cA-MSC) MSCs were evaluated. Among the different parameters tested, only time and temperature influenced MSC number during the experimental shipping conditions.

Category: Biologics
Authors: Smith TJ, Baltzer WI, Löhr C, Stieger-Vanegas SM.
Journal: VCOT

A two-year-old, 97 kg, male neutered English Mastiff was evaluated for left pelvic limb lameness of five months duration localized to the stifle joint. Following radiographic, computed tomographic and arthroscopic examination, the lameness was subsequently diagnosed as being caused by primary synovial osteochondromatosis. In total, 194 osteochondral bodies were removed using arthroscopy in combination with a mini-arthro-tomy. Histology and immunohistochemistry of the loose osteochondral fragments confirmed the diagnosis with a moderately high degree of differentiation and low cellularity.

Authors: Fitzpatrick N, Yeadon R, van Terheijden C, Smith TJ.
Journal: VCOT

Objective: To describe the clinical application of osteochondral autograft transfer procedure for the treatment of osteochondritis dissecans (OCD) of the canine medial femoral condyle and to report clinical and force plate outcomes. Methods: Osteochondral autograft transfer (OATS™ Arthrex, Naples FL, USA) instrumentation was employed in six stifle joints of five dogs. Clinical examination was performed preoperatively and at two to three weeks, six to eight weeks, 12-18 weeks and at >22 months postoperatively.

Authors: Nakladal B, Vom Hagen F, Olias P, Brunnberg L.
Journal: VCOT

This report describes a case of intraosseous lipoma in a two-year-old Leonberger. The dog was presented with a history of ten month lameness in the right forelimb. A massive swelling from the elbow to the carpus of the right forelimb was visible. Treatment with anti-inflammatory medications by the local veterinarian for ten months was unsuccessful and the dog was presented at the university clinic. Radiographic images showed that the diaphyseal part of the ulna was affected by extensive cyst-like osteolysis. Furthermore, the distal metaphysis of the radius showed cyst-like osteolytic changes.

Authors: 1. Nicholas D. Jeffery BVSc, PhD, FRCVS, Diplomate ECVN & ECVS1, 2. Nicolas Granger DVM Diplomate ECVN2
Journal: Vet Surg

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