Biologics

Authors: Medl N, Guerrero TG, Hölzle L, Hässig M, Lochbrunner S, Montavon PM.
Journal: Vet Surg

OBJECTIVE: To (1) determine suction tip (intermittent and continuous mode) contamination rate in orthopedic surgery in dogs and cats; (2) examine the effect of surgical time on contamination; and (3) report bacteria isolated. STUDY DESIGN: Clinical study. SAMPLE POPULATION: Clean orthopedic surgeries (n = 50). METHODS: Surgical procedures were assigned to 1 of 2 groups: (1) continuous (n = 25) or (2) intermittent suction (n = 25). A control suction was operated in each surgery.

Authors: Webb TL, Quimby JM, Dow SW.
Journal: J Feline Med Surg

Mesenchymal stem cells (MSC) are increasingly being proposed as a therapeutic option for a variety of different diseases in human and veterinary medicine. At present, MSC are most often collected from bone marrow (BM) or adipose tissue (AT) and enriched and expanded in vitro before being transferred into recipients. However, little is known regarding the culture characteristics of feline BM-derived (BM-MSC) versus AT-derived MSC (AT-MSC). We compared BM-MSC and AT-MSC from healthy cats with respect to in vitro growth and cell surface phenotype.

Category: Biologics
Authors: Ireifej S, Marino DJ, Loughin CA, Lesser ML, Akerman M.
Journal: Vet Surg

OBJECTIVE:
To report incidence and relevance of positive intraoperative total hip replacement (THR) bacterial cultures taken at the time of surgical closure in dogs having unilateral THR.
STUDY DESIGN:
Retrospective case series.
ANIMALS:
Dogs (n = 100) with cemented (CFX), cementless (BFX), or hybrid THR.
METHODS:

Authors: Little JP, Horn TJ, Marcellin-Little DJ, Harrysson OL, West HA.
Journal: AJVR

Objective-To design and fabricate fiberglass-reinforced composite (FRC) replicas of a canine radius and compare their mechanical properties with those of radii from dog cadavers. Sample-Replicas based on 3 FRC formulations with 33%, 50%, or 60% short-length discontinuous fiberglass by weight (7 replicas/group) and 5 radii from large (> 30-kg) dog cadavers. Procedures-Bones and FRC replicas underwent nondestructive mechanical testing including 4-point bending, axial loading, and torsion and destructive testing to failure during 4-point bending.

Authors: Fitzpatrick N, Smith TJ, Pendegrass CJ, Yeadon R, Ring M, Goodship AE, Blunn GW.
Journal: Vet Surg

OBJECTIVE:
To report clinical application of intraosseous transcutaneous amputation prosthesis (ITAP) for limb salvage.
STUDY DESIGN:
Retrospective case series.
SAMPLE POPULATION:
Client owned dogs with malignant neoplasia of the distal aspect of the limb.
METHOD:

Authors: Kukanich B, Bidgood T, Knesl O.Kukanich B, Bidgood T, Knesl O.
Journal: Vet Anaesth Analg

Objectives   To discuss the clinical pharmacology of currently licensed veterinary NSAIDs and to review gastrointestinal and renal adverse effects as well as drug-drug interactions that have been reported with these drugs. To review the use of NSAIDs in the peri-operative setting and their use in patients with osteoarthritis. To further review the reported effects of NSAIDs on canine articular cartilage and liver as well as the clinical relevance of a washout period.

Authors: Farrell M, Lindsay S, Johnson V, Child G.
Journal: VCOT

An eight-month-old mixed-breed dog was presented with a history of sudden onset pelvic limb lameness. Radiographic and computed tomographic examinations demonstrated an osteolytic process involving the lumbar spine and pelvis. A comprehensive work-up including serial radiographic skeletal survey, biopsy, routine laboratory investigation and evaluation of parathyroid hormone (PTH) and 25-hydroxy-vitamin D levels failed to reveal any underlying cause for the osteolysis.

Authors: Dugat D, Rochat M, Ritchey J, Payton M.
Journal: VCOT

OBJECTIVES:
To quantitatively describe the intramedullary arterial supply of the adult feline tibia and determine if the arterial supply is significantly different from that of adult small dogs.
METHODS:

Authors: Nishida H, Nakayama M, Tanaka H, Kitamura M, Hatoya S, Sugiura K, Suzuki Y, Ide C, Inaba T.
Journal: AJVR

Objective-To evaluate effects of transplantation of bone marrow stromal cells (BMSCs) into the CSF for the treatment of chronic spinal cord injury in dogs that had not responded by 1 month after decompressive surgery. Animals-23 dogs. Procedures-Dogs with paraplegia and loss of nociception in the pelvic limbs for at least 1 month after decompressive surgery were assigned to transplantation or control groups. Dogs in the transplantation group received BMSCs injected into the CSF 1 to 3 months after decompressive surgery. Dogs in the control group did not receive additional treatments.

Authors: Alves EG, Rezende CM, Serakides R, Pereira Mde M, Rosado IR.
Journal: J Feline Med Surg

The purpose of this study was to evaluate the tissue response to a 70% polyhydroxybutyrate and 30% hydroxyapatite composite in the form of a bone implant, placed intracortically in the distal metaphyseal of the right femur, and subcutaneous implants in cats. Samples of the composite were implanted subcutaneously in the dorsolumbar region and the distal metaphyseal region of the right femur of the animals. The study used 12 neutered adult mixed breed cats, weighing an average of 3.5kg.