Objective—To determine the response of cortical bone to a multicomponent and nanostructural polymeric matrix as a drug delivery system for enhancing bone healing.
Animals—20 healthy adult crossbred goats.
Research
Journal: American Journal of Veterinary Research
Journal: Veterinary and Comparative Orthopaedics and Traumatology
Objective: Characterization of a model of reversible foot lameness in the horse. Methods: Both forelimb hooves were fitted with a circumferential clamp. After three baseline measurements utilizing a force platform, one clamp was tightened to induce a grade 2.5/5 lameness and left in place for 120 hours. Serial heart rate and force platform measurements were obtained and the asymmetry index was calculated. After 120 hours, the clamp was released and force platform data recorded until the horse returned to soundness. The procedure was repeated for the opposite forelimb.
Journal: Veterinary Surgery
Objective
To evaluate biocompatibility of biodegradable sleeves containing antimicrobial agents, designed for local drug delivery to prevent implant-related infection.
Study Design
Synthetic polyester sleeves (a copolymer of glycolide, caprolactone, trimethylene carbonate, lactide) were cast as thin films. The antimicrobial agents incorporated in the sleeves included gentamicin sulfate, triclosan, or a combination of these drugs.
Animals
Adult sheep (n = 15).
Methods
Category: Fracture repair - Research - Ruminant
Journal: American Journal of Veterinary Research
Objective—To determine elution characteristics of bone morphogenetic protein (BMP)-2 from a polycaprolactone coating applied to orthopedic implants and determine effects of this coating on osseointegration.
Animals—6 sheep.
Journal: American Journal of Veterinary Research
Objective—To evaluate scintigraphy, radiography, and histomorphometric analysis for assessing incorporation of intercalary bone grafts and to compare incorporation of cortical autografts and allografts by the recipient.
Animals—12 skeletally mature sheep.