Polymethylmethacrylate (PMMA) is the most commonly used filler material that lacks biological properties and osteoconductivity or osteoinductivity. Platelet gel (PG) is a typical source of growth factors, cytokines and molecules efficient for bone formation and remodeling.
The aim of this study was to evaluate bone healing and regeneration of bone defect in rat model by combining PMMA with PG.