Treatment

Authors: Casper Lindegaard, DVM, PhD; Karina B. Gleerup, DVM; Maj H. Thomsen, DVM; Torben Martinussen, PhD; Stine Jacobsen, DVM, PhD; Pia H. Andersen, DVM, DVSci, PhD
Journal: American Journal of Veterinary Research

Objective—To compare the effects of intra-articular (IA) versus IV administration of morphine on local and systemic inflammatory responses in horses with experimentally induced acute synovitis.

Animals—8 horses.

Category: Equine - Lameness - Treatment
Authors: Sabaté, D.; Homedes, J.; Salichs, M.; Sust, M.; Monreal, L.
Journal: Equine Veterinary Journal

Reasons for performing study: In horses, it has been demonstrated that suxibuzone (SBZ) has a lower gastric ulcerogenic effect than phenylbutazone (PBZ). However, no field trials have been reported comparing the efficacy of the drugs in alleviating lameness.

Objectives: To compare the therapeutic effect of SBZ to that of PBZ when administered orally in lame horses. Acceptability of both products was also compared.

Category: Equine - Lameness - NSAID - Treatment
Authors: de Grauw, J.C.; van de Lest, C. H. A.; Brama, P.A.J.; Rambags, B.P.B.; van Weeren, P. R.
Journal: Equine Veterinary Journal

Reasons for performing study: Meloxicam is a commonly used nonsteroidal anti-inflammatory drug in equine practice, but little is known about its in vivo effects on joint inflammation and cartilage turnover.

Objectives: To study the effects of meloxicam on biomarkers of inflammation, matrix metalloproteinase (MMP) activity, and cartilage biomarkers in joints with experimental synovitis.

Category: Cartilage - Equine - NSAID - Treatment
Authors: Daniel W. Carter DVM and J. Ben Renfroe MD
Journal: Journal of Equine Veterinary Science

Laminitis is an inflammation of the lamina of hoofed animals. According to the United States Department of Agriculture (USDA), laminitis impacts approximately 2% of the horse population each year. Because of the severity of the inflammation and chronic pain, it is frequently necessary to euthanize these horses. Surviving horses may be left useless, with resultant economic and social impact on the industry. Current interventions for laminitis are based on supportive care and alteration of biomechanical forces on the digit.

Category: Equine - Laminitis - Treatment
Authors: Chris D. Bell, DVM; Rick D. Howard, DVM, PhD, DACVS; D. Scott Taylor, DVM, DACVS; Ed D. Voss, DVM, DACVIM; Natasha M. Werpy, DVM, DACVR
Journal: Journal of the American Veterinary Medical Association

Objective—To determine clinical outcome following intrathecal injection of the podotrochlear (navicular) bursa for signs of foot pain in horses evaluated via magnetic resonance imaging (MRI) and evaluate efficacy of corticosteroids administered with or without hyaluronate.

Design—Retrospective case series.

Animals—23 horses.

Procedures—Data collected included signalment, history, intended use, duration and severity of lameness, results of diagnostic anesthesia, radiographic abnormalities, MRI abnormalities, and outcomes for return to use.

Category: Equine - Imaging - Lameness - MRI - Treatment
Authors: C. Byron; A. Stewart; B. Benson; B. Tennent-Brown; J. Foreman
Journal: Veterinary and Comparative Orthopaedics and Traumatology

Objective: To investigate the effects of radial extracorporeal shock wave therapy (RESWT) on radiographic and scintigraphic variables in horses with clinical pain referable to the palmar heel. Methods: Eight clientowner horses with palmar heel pain were treated with RESWT for a total of three treatments. Nuclear scintigraphy and radiography were repeated at the beginning and completion of the study. Scintigram region of interest (ROI) density ratios were calculated and compared between treated limbs, untreated limbs, and a population of comparison limbs from eight horses free of lameness.

Authors: Marc T. Launois, DMV; Jean-Michel E. F. Vandeweerd, DMV, MS; Roland A. R. Perrin, DMV; Laurent Brogniez, DMV; Francis G. Desbrosse, DMV; Peter D. Clegg, MA, VetMB
Journal: Journal of the American Veterinary Medical Association

Case Description—3 horses with lameness localized to the proximal aspect of the metacarpus or metatarsus.

Authors: David D. Frisbie, DVM, PhD; C. Wayne McIlwraith, BVSc, PhD; Chris E. Kawcak, DVM, PhD; Natasha M. Werpy, DVM; Gregory L. Pearce, MStat
Journal: American Journal of Veterinary Research

Abstract
American Journal of Veterinary Research
February 2009, Vol. 70, No. 2, Pages 210-215
doi: 10.2460/ajvr.70.2.210

Evaluation of topically administered diclofenac liposomal cream for treatment of horses with experimentally induced osteoarthritis

David D. Frisbie, DVM, PhD; C. Wayne McIlwraith, BVSc, PhD; Chris E. Kawcak, DVM, PhD; Natasha M. Werpy, DVM; Gregory L. Pearce, MStat

Authors: David D. Frisbie, DVM, PhD; Chris E. Kawcak, DVM, PhD; C. Wayne McIlwraith, BVSc, PhD; Natasha M. Werpy, DVM
Journal: American Journal of Veterinary Research

Objective—To assess clinical, biochemical, and histologic effects of polysulfated glycosaminoglycan (PSGAG) or sodium hyaluronan administered intra-articularly in treatment of horses with experimentally induced osteoarthritis. Animals—24 horses. Procedures—Osteoarthritis was induced arthroscopically in 1 middle carpal joint of all horses. Eight horses received hyaluronan (20 mg) and amikacin (125 mg) intra-articularly on study days 14, 21, and 28. Eight horses received PSGAG (250 mg) and amikacin (125 mg) intra-articularly on study days 14, 21, and 28.

Authors: Dutton, D.W.; Lashnits, K.J.; Wegner, K.
Journal: Equine Veterinary Education

This report describes a clinically useful modified composite pain score (MCPS) for horses with hoof pain. The horse in this report initially suffered from acute pain from a subsolar seroma as well as suspected pain from chronic laminitis. Following surgical debridement, corium prolapsed through the wound and it became infected. During the course of conventional hoof and wound management, the pain experienced by the patient was refractory to nonsteroidal anti-inflammatory drugs.

Category: Equine - Treatment